New research suggests that people who stop using popular weight-loss injections like Wegovy and Mounjaro may regain shed pounds at a significantly accelerated pace than those who halt traditional diet and exercise programs.
Research printed in a leading medical journal points out that while obese individuals frequently drop substantial amounts of their body weight while using the jabs, the mass is regained at an average rate of 0.8 kg per month once they quit.
"Individuals using these medications must be aware of the potential of rapid rebound weight gain when the medication concludes," warns expert Dr. Susan Jebb.
This pace of regain suggests a return to starting weight within about 18 months.
Weighing Therapies
The analysis, which examined dozens of trials involving over 9,000 of patients, compared the results of these new drugs with conventional dieting.
Scientists point out that individuals who lose weight through dieting generally have a less rapid weight regain—around 0.1 kg a month—post-intervention.
The Reason for the Quick Rebound
Experts propose the way of the drugs explains the amplified rebound.
These medications imitate a natural hormone called GLP-1, which helps regulate hunger.
"Artificially providing the hormone concentrations far above than the body's typical production could lead to the system to generate a reduced amount of its own natural hormone, and may also reduce sensitivity to its effects," said Dr. Adam Collins, a nutrition specialist.
"Stopping of this medication results in appetite is no longer kept in check, making excessive eating a significant risk."
A Lifelong Condition?
Medical guidelines suggest the jabs for people with weight-linked health risks, accompanied by recommended diet and exercise modifications.
Professionals contend that, due to the high risk of weight regain, the therapy should be considered long-term.
This view is supported by drug manufacturers, who note that the findings "highlight the chronic character of excess weight," akin to managing diseases like hypertension.
Patient Accounts
Users who have discontinued the medication describe a intense resurgence of appetite.
"It was like a switch flipping and you become starving," described one woman.
This difficulty is worsened if individuals have not adopted lasting lifestyle or habit changes during treatment.
Growing Interest
Survey data indicate that millions of people in the UK have used weight-loss jabs in the last 12 months, with interest being substantial.
- Use is higher among women than men.
- The middle-aged demographic shows the greatest level of interest.
- A large proportion obtain the drugs through private prescriptions rather than the NHS.
Ultimately, experts emphasize that while GLP-1 drugs are powerful tools for shedding pounds, they are not a standalone solution and lasting health benefits likely depends on ongoing behavioural management.
